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Capsaicin and its health benefits
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Capsaicin and its health benefits
In a recent study published in the journal Nutrients, researchers in Australia examine the health benefits associated with capsaicin, with a particular focus on how this compound impacts cognition and cardiovascular health.Get more news about capsaicin powder factory,you can vist our website!
What is capsaicin?
Capsaicinoids, which are the major pungent chemical found in Capsicum-genus plants like chilies, are phenolic compounds that share a vanilloid ring. Capsaicinoids consist of capsaicin, nordihydrocapsaicin, homocapsaicin, dihydrocapsaicin, and homodihydrocapsaicin, of which capsaicin has the highest prevalence. Capsaicin is associated with numerous health benefits including anti-inflammatory, anti-carcinogenic, anti-obesity agent, and antioxidant properties.Capsaicin and cardiometabolic disease
Obesity elevates blood triglycerides, low-density lipoprotein (LDL), and free fatty acids. This contributes to vascular remodeling, nitric oxide synthase (NOS) dysregulation, and atherosclerosis, the latter of which is a major reason for cerebrovascular and cardiovascular disease.Capsaicin enhances thermogenesis, fat oxidation, and energy expenditure, all of which contribute to reduced adiposity. This is accomplished by transient receptor potential vanilloid channel 1 (TRPV1) activation and the subsequent lowering of pro-inflammatory cytokines, such as tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), which are elevated with higher adiposity.
Previously, TRPV1 activation with capsaicin has been shown to reverse defective macrophage autophagy produced by oxidized low-density lipoprotein, as well as activate AMP-activated protein kinase (AMPK) signaling activation, reduce foam cell production, and limit the formation of atherosclerotic plaques.
Aging, cognition, and capsaicin
One of the primary symptoms of dementia is impaired cognition, which can result in functional impairment and diminished quality of life in an aging population. Increased oxidative stress, endothelial dysfunction, and persistent low-grade systemic inflammation are related to aging and can subsequently lead to impaired cerebrovascular function and cognitive impairment.Through TRPV1 activation, capsaicin has been shown to improve cognition in vivo. To this end, TRPV1 activation induced by capsaicin leads to reduced adiposity, oxidative stress, and chronic low-grade systemic inflammation, all of which are associated with both cerebrovascular function and cognition.